Investigating Hastily-Formed Collaborative Networks

This research explores both the human and technical aspects of the network centric environment in the context of a major disaster or incident of national significance. The National Incident Management System (NIMS) is viewed by the authors as a social network, and an organizational topology is developed to improve its effectiveness. A rapid Network Deployment Kit (RNDK) using commercial off the shelf (COTS) wireless networking technology is also proposed that facilitates immediate NIMS implementation. The integration of logical and technical analyses forms a comprehensive systems engineering proposal to facilitate collaboration in a net-centric environment. It is envisioned that the methodology used herein to derive and evaluate comprehensive networks proves extendable to other contexts thereby contributing to the netcentric body of knowledge

Hear my screams: An auto-ethnographic account of the police

Other writers, notably police researchers, infrequently discuss the problems and difficulties that they encounter in and outside of fieldwork when doing research on the police. In this article, I piece together some critical and personal reflections of researching the police to provide nuanced information that can help other writers to learn from my own experiences of researching the police and also help them to navigate their own experiences of working with the police for research purposes. These reflections of mine emanate from fieldwork notes and my research diary. I use Ahmed’s The Promise of Happiness as a lens to theorise and make sense of such experiences, understanding how my presence gets in the way of the happiness of others because of my affiliation to sexual violence work. By naming a problem, rape as a problem, I became the problem. The article outlines some of the chief ethical, personal and pragmatic issues that can surface when researching the police. For example, I frequently encountered interrogative questions whereby officers questioned my sexuality, asking ‘are you gay?’ I became a nuisance for the police, a problem by highlighting the issue of male rape as a problem given that it challenges the status quo of normative heterosexuality. I argue that, doing research on the police, which can involve sensitive and challenging work that affects one emotionally, socially and physically, impacts not only the officers being interviewed, but also the researchers themselves. The latter group should be identified much more readily than seems to be the case in the social sciences

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). In contrast, ALS-associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS.Peer reviewe